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complement activation中文是什么意思

  • 補(bǔ)體激活

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  • 例句與用法
  • Standard practice for testing for whole complement activation in serum by solid materials
    用固體材料測(cè)試血漿中整個(gè)活性的標(biāo)準(zhǔn)操作規(guī)程
  • Standard practice for testing for alternative pathway complement activation in serum by solid materials
    通過固體材料測(cè)試血清中替換途徑互補(bǔ)活化性的標(biāo)準(zhǔn)實(shí)施規(guī)程
  • However , complement activation presents a potential threat to host cells , as inappropriate activation may lead to tissue damage in many diseases
    然而,對(duì)機(jī)體來說,補(bǔ)體也具有潛在的威脅,其經(jīng)過不適宜的活化后,可以導(dǎo)致機(jī)體多種組織的損傷。
  • An array of regulatory proteins have been found , which inhibit the formation of central enzymes involved in early stages of the complement activation pathway . these include membrane cofactor protein ( mcp cd46 ) , decay - accelerating factor protein ( daf cd5 5 ) , complement receptor 1 ( cr1 , cd35 ) , as well as cd59 , which inhibits formation of the membrane attack complex during later stages . these regulatory factors are widely expressed and abundant on many cells , and in fluids of reproductive system
    目前發(fā)現(xiàn),機(jī)體多種細(xì)胞以及生殖系統(tǒng)的體液中表達(dá)和分泌豐富的補(bǔ)體調(diào)控蛋白,包括作用于補(bǔ)體活化早期階段的cd55 、 cd46 、 cd35和作用于補(bǔ)體活化終末階段的cd59 ,它們分別通過抑制補(bǔ)體活化過程中關(guān)鍵的c3 、 c5轉(zhuǎn)化酶和抑制形成膜攻擊單位,抵抗補(bǔ)體對(duì)自身組織細(xì)胞的攻擊。
  • We focused on the following aspects ; 1 ) we first assayed the expression of complement receptors and complement - associated molecules on distinct subsets of dendritic cells during their development in order to understand the physical basis of the sensitivity of dendritic cells to complement and its split products ; we next studied the effects of complement activation on the survival of dendritic cells during their development ; and finally examined the effects of the whole complement system , focusing on the ability of one of the split products of complement activation , c5a , and its first subcomponent - c1q , to influence chemotaxis of dendritic cells , as well as allo - t cell stimulatory activity of dc
    我們通過免疫磁珠分離了兩種人dc前體,即髓系來源的單核細(xì)胞( monocytes , mo )和淋巴系來源的漿細(xì)胞樣dc ( plasmaeytoiddendriticeells , pdc ) ,對(duì)這兩個(gè)不同dc亞群進(jìn)行體外誘導(dǎo)培養(yǎng),使其處于不同的分化發(fā)育階段,然后檢測(cè)了其表達(dá)補(bǔ)體受體一cd35 ( cri ) 、 cd21 ( crz ) 、 cdilb ( cr3 ) 、 cdlle ( cr4 ) ,補(bǔ)體調(diào)控蛋白一cd46 、 cd55 、以及部分補(bǔ)體片斷分子受體一c3ar 、 csar 、 clqrp的水平。
  • As an important innate immune system , and as an important arm of the humoral immune response , the complement system is immediately ready to target and eliminate virus particles , to lysis those virions that have lipoprotein membranes , or to prevent it from entering host cells , or to marker them for destruction by other branch of the immune response . at the same time , the host normal tissue are protected from damaging by complement through recognizing the regulators of complement activation ( rca ) expressed on self cells
    作為機(jī)體重要的天然免疫防御系統(tǒng)及特異性體液免疫應(yīng)答的重要效應(yīng)系統(tǒng),補(bǔ)體系統(tǒng)除了具有溶解、清除病毒等致病微生物,阻止病毒進(jìn)入靶細(xì)胞,調(diào)理病毒的吞噬等重要功能外,還可通過“識(shí)別”自身組織細(xì)胞表面的補(bǔ)體活化調(diào)節(jié)蛋白來對(duì)自身細(xì)胞加以保護(hù),使之不受侵害。
  • Almost one - third of all proteases can be classified as serine proteases , including complement subcomponent clr / cls , mannose - associated serine proteases ( masps ) , ovochymase , spermadhesin , type ii transmembrane serine proteases ( ttsps ) etc . these proteins are involved in diverse biological processes , including developmental processes such as complement activation , ovulation , fertilization , tissue remodeling , cellular migration , cancer invasion and metastasis , intestinal digestion , embryogenesis , or organogenesis
    絲氨酸蛋白酶( serineprotease )是機(jī)體最重要的酶分子之一,約占機(jī)體蛋白酶的三分之一,我們較熟知的絲氨酸蛋白酶就包括補(bǔ)體組分c1r c1s 、甘露糖結(jié)合絲氨酸蛋白酶、 ovochymase 、 spermadhesin和型跨膜絲氨酸蛋白酶等,它們參與了補(bǔ)體活化、排卵、授精、組織重建、細(xì)胞遷移、腫瘤浸潤(rùn)和轉(zhuǎn)移、消化、胚胎發(fā)育、器官形成等多項(xiàng)生理功能。
  • To answer this question , a bispecific , trifunctional antibody constructs which can not only target block virus incorporated rca , but also can induce complement activation by it ' s fc fragment were designed and constructed and iv the role of this kind of bispecific antibody in virus neutralization was studied . 1 . to test our idea , human immunodeficient virus ( hiv ) and enveloped extracellular virus ( eev ) of vaccinia virus ( vv ) were selected in our study because of their complex immune evasion stratiges , their threaten to humans , and because both these two kinds of virus can escape complement attack by incorporating host rca into their envelope
    以嚴(yán)重危害人類健康,且具有復(fù)雜免疫逃避機(jī)制的有包膜的hiv病毒及痘苗病毒的eev病毒為研究對(duì)象,首先對(duì)它們逃避補(bǔ)體攻擊的現(xiàn)象進(jìn)行了驗(yàn)證,探討了宿主膜補(bǔ)體調(diào)節(jié)蛋白cd55 、 cd59與hiv病毒及eev病毒免疫逃避的關(guān)系,評(píng)價(jià)了病毒結(jié)合的這兩種補(bǔ)體調(diào)節(jié)蛋白作為本研究提出的,通過消除病毒逃避補(bǔ)體攻擊的機(jī)制來恢復(fù)病毒對(duì)補(bǔ)體攻擊的敏感性,提高補(bǔ)體抗病毒效率這一抗病毒策略的靶點(diǎn)的可能性。
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