complement n. 1.補(bǔ)足(物);補(bǔ)全;互補(bǔ)(成分),補(bǔ)充。 2.(必需的)定量,全量;整套,整組;【航?!?船員的)定額;【軍事】編制人數(shù),定額裝備。 3.【語法】補(bǔ)(足)語;【數(shù)學(xué)】余角,余弧,余數(shù);余集;【計(jì)算機(jī)】補(bǔ)數(shù),補(bǔ)碼;反碼;【音樂】補(bǔ)足音程;【生物學(xué)】補(bǔ)體[免疲];組[細(xì)胞]。 The regiment had its complement of men. 這個(gè)團(tuán)的兵員已足額。 complement of nine's 十進(jìn)制反碼。 complement of one's 二進(jìn)制反碼。 complement of ten's 十進(jìn)制補(bǔ)碼。 complement of two's 二進(jìn)制補(bǔ)碼。 complement of an angle 余角。 vt. 補(bǔ)充,補(bǔ)足。 complement each other 互為補(bǔ)充。
Standard practice for testing for whole complement activation in serum by solid materials 用固體材料測(cè)試血漿中整個(gè)活性的標(biāo)準(zhǔn)操作規(guī)程
Standard practice for testing for alternative pathway complement activation in serum by solid materials 通過固體材料測(cè)試血清中替換途徑互補(bǔ)活化性的標(biāo)準(zhǔn)實(shí)施規(guī)程
However , complement activation presents a potential threat to host cells , as inappropriate activation may lead to tissue damage in many diseases 然而,對(duì)機(jī)體來說,補(bǔ)體也具有潛在的威脅,其經(jīng)過不適宜的活化后,可以導(dǎo)致機(jī)體多種組織的損傷。
An array of regulatory proteins have been found , which inhibit the formation of central enzymes involved in early stages of the complement activation pathway . these include membrane cofactor protein ( mcp cd46 ) , decay - accelerating factor protein ( daf cd5 5 ) , complement receptor 1 ( cr1 , cd35 ) , as well as cd59 , which inhibits formation of the membrane attack complex during later stages . these regulatory factors are widely expressed and abundant on many cells , and in fluids of reproductive system 目前發(fā)現(xiàn),機(jī)體多種細(xì)胞以及生殖系統(tǒng)的體液中表達(dá)和分泌豐富的補(bǔ)體調(diào)控蛋白,包括作用于補(bǔ)體活化早期階段的cd55 、 cd46 、 cd35和作用于補(bǔ)體活化終末階段的cd59 ,它們分別通過抑制補(bǔ)體活化過程中關(guān)鍵的c3 、 c5轉(zhuǎn)化酶和抑制形成膜攻擊單位,抵抗補(bǔ)體對(duì)自身組織細(xì)胞的攻擊。
We focused on the following aspects ; 1 ) we first assayed the expression of complement receptors and complement - associated molecules on distinct subsets of dendritic cells during their development in order to understand the physical basis of the sensitivity of dendritic cells to complement and its split products ; we next studied the effects of complement activation on the survival of dendritic cells during their development ; and finally examined the effects of the whole complement system , focusing on the ability of one of the split products of complement activation , c5a , and its first subcomponent - c1q , to influence chemotaxis of dendritic cells , as well as allo - t cell stimulatory activity of dc 我們通過免疫磁珠分離了兩種人dc前體,即髓系來源的單核細(xì)胞( monocytes , mo )和淋巴系來源的漿細(xì)胞樣dc ( plasmaeytoiddendriticeells , pdc ) ,對(duì)這兩個(gè)不同dc亞群進(jìn)行體外誘導(dǎo)培養(yǎng),使其處于不同的分化發(fā)育階段,然后檢測(cè)了其表達(dá)補(bǔ)體受體一cd35 ( cri ) 、 cd21 ( crz ) 、 cdilb ( cr3 ) 、 cdlle ( cr4 ) ,補(bǔ)體調(diào)控蛋白一cd46 、 cd55 、以及部分補(bǔ)體片斷分子受體一c3ar 、 csar 、 clqrp的水平。
As an important innate immune system , and as an important arm of the humoral immune response , the complement system is immediately ready to target and eliminate virus particles , to lysis those virions that have lipoprotein membranes , or to prevent it from entering host cells , or to marker them for destruction by other branch of the immune response . at the same time , the host normal tissue are protected from damaging by complement through recognizing the regulators of complement activation ( rca ) expressed on self cells 作為機(jī)體重要的天然免疫防御系統(tǒng)及特異性體液免疫應(yīng)答的重要效應(yīng)系統(tǒng),補(bǔ)體系統(tǒng)除了具有溶解、清除病毒等致病微生物,阻止病毒進(jìn)入靶細(xì)胞,調(diào)理病毒的吞噬等重要功能外,還可通過“識(shí)別”自身組織細(xì)胞表面的補(bǔ)體活化調(diào)節(jié)蛋白來對(duì)自身細(xì)胞加以保護(hù),使之不受侵害。
Almost one - third of all proteases can be classified as serine proteases , including complement subcomponent clr / cls , mannose - associated serine proteases ( masps ) , ovochymase , spermadhesin , type ii transmembrane serine proteases ( ttsps ) etc . these proteins are involved in diverse biological processes , including developmental processes such as complement activation , ovulation , fertilization , tissue remodeling , cellular migration , cancer invasion and metastasis , intestinal digestion , embryogenesis , or organogenesis 絲氨酸蛋白酶( serineprotease )是機(jī)體最重要的酶分子之一,約占機(jī)體蛋白酶的三分之一,我們較熟知的絲氨酸蛋白酶就包括補(bǔ)體組分c1r c1s 、甘露糖結(jié)合絲氨酸蛋白酶、 ovochymase 、 spermadhesin和型跨膜絲氨酸蛋白酶等,它們參與了補(bǔ)體活化、排卵、授精、組織重建、細(xì)胞遷移、腫瘤浸潤(rùn)和轉(zhuǎn)移、消化、胚胎發(fā)育、器官形成等多項(xiàng)生理功能。
To answer this question , a bispecific , trifunctional antibody constructs which can not only target block virus incorporated rca , but also can induce complement activation by it ' s fc fragment were designed and constructed and iv the role of this kind of bispecific antibody in virus neutralization was studied . 1 . to test our idea , human immunodeficient virus ( hiv ) and enveloped extracellular virus ( eev ) of vaccinia virus ( vv ) were selected in our study because of their complex immune evasion stratiges , their threaten to humans , and because both these two kinds of virus can escape complement attack by incorporating host rca into their envelope 以嚴(yán)重危害人類健康,且具有復(fù)雜免疫逃避機(jī)制的有包膜的hiv病毒及痘苗病毒的eev病毒為研究對(duì)象,首先對(duì)它們逃避補(bǔ)體攻擊的現(xiàn)象進(jìn)行了驗(yàn)證,探討了宿主膜補(bǔ)體調(diào)節(jié)蛋白cd55 、 cd59與hiv病毒及eev病毒免疫逃避的關(guān)系,評(píng)價(jià)了病毒結(jié)合的這兩種補(bǔ)體調(diào)節(jié)蛋白作為本研究提出的,通過消除病毒逃避補(bǔ)體攻擊的機(jī)制來恢復(fù)病毒對(duì)補(bǔ)體攻擊的敏感性,提高補(bǔ)體抗病毒效率這一抗病毒策略的靶點(diǎn)的可能性。